Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience & Nijmegen Centre for Molecular Life Sciences (NCMLS), Faculty of Science, Radboud University Nijmegen, 6525 GA, Nijmegen, The Netherlands.
Curr Neuropharmacol. 2010 Dec;8(4):382-93. doi: 10.2174/157015910793358132.
The complex neurodevelopmental disorder schizophrenia is thought to be induced by an interaction between predisposing genes and environmental stressors. In order to get a better insight into the aetiology of this complex disorder, animal models have been developed. In this review, we summarize mRNA expression profiling studies on neurodevelopmental, pharmacological and genetic animal models for schizophrenia. We discuss parallels and contradictions among these studies, and propose strategies for future research.
精神分裂症是一种复杂的神经发育障碍，据认为是由易感基因和环境应激源相互作用引起的。为了更好地了解这种复杂疾病的病因，已经开发了动物模型。在这篇综述中，我们总结了神经发育、药理学和遗传精神分裂症动物模型的 mRNA 表达谱研究。我们讨论了这些研究之间的相似之处和矛盾之处，并提出了未来研究的策略。
