Koley J, Sinha S, Basak A K, Das M, Dube S N, Majumder P K, Gupta A K, Dasgupta S, Koley B
Department of Physiology, University College of Science and Technology, Calcutta, India.
Eur J Pharmacol. 1995 Dec 7;293(4):483-6. doi: 10.1016/0926-6917(95)90069-1.
The present study demonstrated cardiorespiratory effects of a synthetic phosphorus-containing ichthyotoxic metabolite elaborated by the marine dinoflagellate Ptychodiscus brevis in anaesthetised cats. The metabolite at a dose of 0.25-1.5 mg/kg i.v., resulted in a dose-dependent fall in blood pressure and such vasodepressor effect was associated with bradycardia. There is initial respiratory apnoea followed by increased rate and depth of respiration (hyperapnoea) following the administration of the toxin. The hypotensive response was accompanied by a decrease in aortic baroreceptor activity. The ECG showed atrioventricular conduction block, arrhythmia and depression of S-T segment and T wave which indicated coronary insufficiency. Vasodepressive property of the toxin is presumably muscarinic in nature as atropine counteracted the vasodepression.
本研究证明了海洋甲藻短裸甲藻产生的一种合成含磷鱼毒素代谢产物对麻醉猫的心肺效应。静脉注射剂量为0.25 - 1.5毫克/千克的该代谢产物，会导致血压呈剂量依赖性下降，这种血管减压效应与心动过缓有关。注射毒素后，起初会出现呼吸暂停，随后呼吸频率和深度增加（呼吸增强）。降压反应伴随着主动脉压力感受器活动的降低。心电图显示房室传导阻滞、心律失常以及S-T段和T波压低，这表明存在冠状动脉供血不足。毒素的血管减压特性可能本质上是毒蕈碱样的，因为阿托品可对抗血管减压作用。
