Duijkers I J, Magnusson Y M, Hollanders H M
Department of Obstetrics and Gynecology, University Hospital Nijmegen St. Radboud, The Netherlands.
Int J Fertil Menopausal Stud. 1995 Nov-Dec;40(6):307-10.
The present study investigated the pharmacokinetics of a single subcutaneous dose of human menopausal gonadotropin (hMG) on serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) concentrations.
Six healthy female volunteers, aged 20-40 years, with regular menstrual cycles and normal endocrine profiles, who were not receiving any hormonal medication, were treated with the gonadotropin-releasing-hormone agonist buserelin to suppress endogenous gonadotropin release. One volunteer dropped out during treatment. When the serum estradiol concentration had fallen to below 500 pmol/L, an injection of 150 IU hMG (HumegonR) was given subcutaneously. Immediately before injection and 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 15, 20, 24, 48 and 96 hours after, blood samples were drawn for determination of FSH and LH concentrations.
The baseline FSH level was 2.8 IU/L, and peak concentration (6.8 IU/L) was reached 12 hours after hMG injection (median values). Exogenous LH could not be measured because of the presence of endogenous LH.
The pattern of serum FSH concentrations after a single injection of hMG was found to resemble that seen after intramuscular hMG administration, although the peak FSH value was reached somewhat later.
本研究调查了单次皮下注射人绝经期促性腺激素（hMG）对血清卵泡刺激素（FSH）和黄体生成素（LH）浓度的药代动力学。
6名年龄在20 - 40岁之间、月经周期规律且内分泌状况正常、未接受任何激素药物治疗的健康女性志愿者，接受促性腺激素释放激素激动剂布舍瑞林治疗以抑制内源性促性腺激素释放。一名志愿者在治疗期间退出。当血清雌二醇浓度降至500 pmol/L以下时，皮下注射150 IU hMG（HumegonR）。在注射前以及注射后0.5、1、2、3、4、6、8、10、12、15、20、24、48和96小时采集血样，测定FSH和LH浓度。
基线FSH水平为2.8 IU/L，hMG注射后12小时达到峰值浓度（6.8 IU/L）（中位数）。由于内源性LH的存在，无法检测到外源性LH。
单次注射hMG后血清FSH浓度的变化模式与肌肉注射hMG后相似，尽管FSH峰值出现时间稍晚。
