Moore P, Hanson-Painton O, Morgenstern K, Grammas P
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Mol Chem Neuropathol. 1995 Dec;26(3):259-68. doi: 10.1007/BF02815142.
Regulation of protein kinase C (PKC)-mediated responses may occur by inhibition of PKC-dependent phosphorylation or by dephosphorylation of targets by specific phosphatases. Mechanisms for the regulation of PKC were examined in isolated cerebral microvessels and compared to those in brain. The data demonstrated that inhibitors of phosphorylation are responsible for the regulation in brain microvessels while dephosphorylation by protein phosphatases accounts for a substantial portion of the regulation of the PKC response in brain. In addition, the inhibitory activity apparently increases with age. These results suggest that the control of PKC may be cell-type specific and developmentally regulated.
蛋白激酶C（PKC）介导的反应调节可能通过抑制PKC依赖性磷酸化或通过特定磷酸酶使靶标去磷酸化来实现。在分离的脑微血管中研究了PKC的调节机制，并与脑中的机制进行了比较。数据表明，磷酸化抑制剂负责脑微血管中的调节，而蛋白磷酸酶的去磷酸化则占脑中PKC反应调节的很大一部分。此外，抑制活性显然随年龄增长而增加。这些结果表明，PKC的控制可能是细胞类型特异性的且受发育调控。
