Mizumori S J, Garcia P A, Raja M A, Volpe B T
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
Behav Neurosci. 1995 Dec;109(6):1081-94. doi: 10.1037//0735-7044.109.6.1081.
Spatial and locomotion-related behavioral correlates of hippocampal cell discharge were compared between ischemic and sham-control rats performing a spatial maze. Ischemic rats showed impaired choice accuracy during maze acquisition, but not during asymptote performance. Single-unit correlates during asymptote performance revealed enhanced spatial selectivity of CA2/3 complex-spike cells coincident with attenuated place-specific firing by hilar complex-spike or subicular cells. Responsivity to locomotion state by stratum granulosum interneurons was exaggerated, and locomotion-induced changes in firing of hilar and subicular interneurons was reduced. Ischemic rats showed recovered spatial learning abilities as evidenced by the fact that acquisition of the spatial task in a second environment was not impaired. Because representational reorganization was also observed in ischemic, maze-naive rats, brain injury per se appears to change information coding schemes.
在执行空间迷宫任务的缺血大鼠和假手术对照大鼠之间，比较了海马细胞放电与空间及运动相关的行为相关性。缺血大鼠在迷宫学习过程中表现出选择准确性受损，但在渐近线表现期间未受损。渐近线表现期间的单单位相关性显示，CA2/3复合峰细胞的空间选择性增强，同时门区复合峰或下托细胞的位置特异性放电减弱。颗粒层中间神经元对运动状态的反应性增强，而门区和下托中间神经元放电的运动诱导变化减少。缺血大鼠表现出空间学习能力的恢复，这一事实证明在第二个环境中进行空间任务学习并未受损。由于在未接触过迷宫的缺血大鼠中也观察到了表征重组，因此脑损伤本身似乎会改变信息编码方案。
