Persinger M A, Bureau Y R, Peredery O
Behavioral Neuroscience Program, Laurentian University, Sudbury, Ontario, Canada.
Physiol Behav. 1994 Aug;56(2):225-35. doi: 10.1016/0031-9384(94)90188-0.
Multivariate analyses between conditioned taste aversion (CTA) and radial maze acquisition (RMA) scores and percentages of neuronal dropout within thalamic and telencephalic structures were completed for rats in which overt seizures had been evoked following a single systemic injection of lithium/pilocarpine. Despite multifocal damage, only the amount of damage within the hippocampus (CA1) and the basolateral amygdala was most strongly associated with attenuated CTA, whereas damage within the mediodorsal thalamus was primarily associated with RMA. There was no significant correlation between CTA or RMA. Multiple regression analyses for specific Paxinos and Watson structures and their traditional aggregates supported more precise delineation of neuronal substrates of learning/memory and a multimodal (parallel) model for these processes.
对单次全身注射锂/毛果芸香碱后诱发明显癫痫发作的大鼠，完成了条件性味觉厌恶（CTA）和放射状迷宫获取（RMA）分数与丘脑和端脑结构内神经元脱失百分比之间的多变量分析。尽管存在多灶性损伤，但仅海马体（CA1）和基底外侧杏仁核内的损伤量与减弱的CTA最密切相关，而中背侧丘脑内的损伤主要与RMA相关。CTA或RMA之间无显著相关性。对特定的帕西诺斯和沃森结构及其传统集合进行的多元回归分析支持了对学习/记忆神经元底物的更精确描绘以及这些过程的多模态（平行）模型。
