硝苯地平增强胆碱能诱导的小鼠运动活动抑制作用。
Enhancement by nifedipine of cholinergic-induced depression of locomotor activity in mice.
作者信息
Sansone M, Battaglia M, Pavone F
机构信息
Institute of Psychobiology and Psychopharmacology, CNR, Rome, Italy.
出版信息
Funct Neurol. 1995 Jul-Oct;10(4-5):163-7.
The dihydropyridine calcium channel blocker nifedipine did not affect spontaneous locomotor activity in mice when given alone but enhanced the depressant effects of the muscarinic receptor agonist oxotremorine and of the acetylcholinesterase inhibitor physostigmine. Such a behavioral depression might be due to neuronal changes induced by central calcium channel blockade combined with cholinergic activation. However, an involvement of hemodynamic factors, related to peripheral vasodilatation, cannot be excluded as locomotor depressant effects were also exerted by combinations of the two cholinomimetic agents with hydralazine, a non-calcium antagonist vasodilator.
二氢吡啶类钙通道阻滞剂硝苯地平单独给药时不影响小鼠的自发运动活性，但可增强毒蕈碱受体激动剂氧化震颤素和乙酰胆碱酯酶抑制剂毒扁豆碱的抑制作用。这种行为抑制可能是由于中枢钙通道阻滞联合胆碱能激活引起的神经元变化所致。然而，不能排除与外周血管扩张相关的血流动力学因素的参与，因为两种拟胆碱药物与非钙拮抗剂血管扩张剂肼屈嗪联合使用时也会产生运动抑制作用。
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