硝苯地平对胆碱能镇痛的减弱作用。
Attenuation of cholinergic analgesia by nifedipine.
作者信息
Pavone F, Battaglia M, Sansone M
机构信息
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
出版信息
Brain Res. 1993 Oct 1;623(2):308-10. doi: 10.1016/0006-8993(93)91443-v.
Nociception was tested in mice receiving oxotremorine or physostigmine either after the dihydropyridine calcium channel blocker nifedipine or the non-calcium antagonist vasodilator hydralazine. Nifedipine did not change the reaction time to thermal stimulation (tail-flick test), but attenuated the prolonging action on tail-flick latencies exerted by the two cholinomimetic agents. Hydralazine had no effect alone nor modified the action of cholinomimetics. The results suggest that attenuation of cholinergic analgesia by nifedipine might be related to not yet defined neuronal changes produced by calcium channel blockade, but changes in the pharmacokinetics of oxotremorine and physostigmine cannot be ruled out.
在给予二氢吡啶类钙通道阻滞剂硝苯地平或非钙拮抗剂血管扩张剂肼屈嗪后，对接受氧化震颤素或毒扁豆碱的小鼠进行伤害感受测试。硝苯地平未改变对热刺激的反应时间（甩尾试验），但减弱了两种拟胆碱药对甩尾潜伏期的延长作用。肼屈嗪单独使用无作用，也未改变拟胆碱药的作用。结果表明，硝苯地平对胆碱能镇痛的减弱可能与钙通道阻滞产生的尚未明确的神经元变化有关，但不能排除氧化震颤素和毒扁豆碱药代动力学的改变。
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