Matsushita M, Fujita T
Department of Biochemistry, Fukushima Medical College, Japan.
Immunobiology. 1995 Nov;194(4-5):443-48. doi: 10.1016/S0171-2985(11)80110-5.
We have previously shown that a novel C1s-like serine protease termed MBP-associated serine protease (MASP) is responsible for activation of the complement cascade initiated by mannose-binding protein (MBP). In this communication, we report that MASP is unique in having the proteolytic capacity to cleave C3 with subsequent activation of the alternative pathway, a capacity which C1s lacks.
我们先前已表明，一种名为甘露糖结合蛋白相关丝氨酸蛋白酶（MASP）的新型C1s样丝氨酸蛋白酶负责激活由甘露糖结合蛋白（MBP）启动的补体级联反应。在本通讯中，我们报告MASP具有独特的蛋白水解能力，可裂解C3并随后激活替代途径，而C1s缺乏这种能力。
