Carkeet N L, Mountford J A, Carney L G
School of Optometry and Centre for Eye Research, Queensland University of Technology, Brisbane, Australia.
Optom Vis Sci. 1995 Dec;72(12):892-8. doi: 10.1097/00006324-199512000-00007.
Orthokeratology procedures suffer from lack of predictability in the response of individuals. To identify factors contributing to this, we have retrospectively studied a range of ocular parameters in patients with varying outcomes from orthokeratology lens wear.
Three groups were studied: an experimental group (9 subjects wearing Contex OK-3 design orthokeratology contact lenses), and 2 control groups [10 rigid gas permeable (RGP) contact lens wearers and 10 non-contact lens wearers]. Three categories were identified among the orthokeratology group: those responding well, moderately, or poorly to orthokeratology lens wear. Measurements included subjective refraction, intraocular distances, corneal thickness, ocular rigidity, and epithelial fragility.
When comparing the three orthokeratology categories, there was no significant difference for central and peripheral epithelial fragility and ocular rigidity. There was also no significant difference for any of the biometric characteristics measured. The prefitting spherical equivalent power was found to be significantly different between categories of responders (p = 0.0228), with the poor responders having the highest initial level of myopia. None of the measured characteristics differed significantly among the orthokeratology group and the two control groups.
In this pilot study, the success of orthokeratology lens wear was not related to ocular biomechanical or biometric attributes, but it was related to prefitting refractive error.
角膜塑形术在个体反应方面缺乏可预测性。为了确定导致这一情况的因素，我们回顾性研究了佩戴角膜塑形镜后出现不同结果的患者的一系列眼部参数。
研究了三组对象：一个实验组（9名佩戴Contex OK - 3设计角膜塑形接触镜的受试者），以及两个对照组[10名硬性透气性（RGP）接触镜佩戴者和10名非接触镜佩戴者]。在角膜塑形术组中确定了三类：对角膜塑形镜佩戴反应良好、中等或较差的人。测量包括主观验光、眼内距离、角膜厚度、眼硬度和上皮脆性。
比较角膜塑形术的三类情况时，中央和周边上皮脆性以及眼硬度没有显著差异。所测量的任何生物特征也没有显著差异。发现不同反应类别之间的预配镜球镜等效度数存在显著差异（p = 0.0228），反应较差者的初始近视程度最高。角膜塑形术组与两个对照组之间所测量的特征均无显著差异。
在这项初步研究中，角膜塑形镜佩戴的成功与否与眼部生物力学或生物特征属性无关，而是与预配镜屈光不正有关。
