Lamothe F, D'Amico P, Ghosn P, Tremblay C, Braidy J, Patenaude J V
Department of Microbiology, Université de Montréal, Canada.
Clin Infect Dis. 1995 Dec;21(6):1469-70. doi: 10.1093/clinids/21.6.1469.
The spectrum of invasive Streptococcus pyogenes (group A streptococcus) infections includes bacteremia, toxic shock syndrome, and necrotizing fasciitis or myositis. We report the successful use of intravenous immunoglobulins in conjunction with antibiotics and surgery in a case of necrotizing myositis, toxic shock, and bacteremia. A literature review revealed that three other patients with invasive group A streptococcal infections had been treated with immunoglobulins: one adult patient had toxic shock syndrome, one had necrotizing fasciitis, and one child had septic arthritis. On the basis of this report and the review, we suggest that intravenous immunoglobulins may be useful in the treatment of all forms of invasive group A streptococcal infections associated with toxic shock syndrome.
侵袭性酿脓链球菌（A 组链球菌）感染谱包括菌血症、中毒性休克综合征以及坏死性筋膜炎或肌炎。我们报告了 1 例坏死性肌炎、中毒性休克和菌血症患者，静脉注射免疫球蛋白联合抗生素及手术治疗成功。文献回顾显示，另有 3 例侵袭性 A 组链球菌感染患者接受了免疫球蛋白治疗：1 例成年患者患有中毒性休克综合征，1 例患有坏死性筋膜炎，1 例儿童患有化脓性关节炎。基于本报告及文献回顾，我们建议静脉注射免疫球蛋白可能有助于治疗与中毒性休克综合征相关的所有形式的侵袭性 A 组链球菌感染。
