Farren C K, Clare A W, Ziedonis D, Hammeedi F A, Dinan T G
Department of Psychiatry, Trinity College, St. Patrick's Hospital, Dublin, Ireland.
Alcohol Clin Exp Res. 1995 Dec;19(6):1520-4. doi: 10.1111/j.1530-0277.1995.tb01017.x.
Dopamine D2 receptor sensitivity was assessed in the postwithdrawal period in alcoholics. Growth hormone (GH) responses to dopamine D2 agonist bromocriptine were measured in eight DSM-III-R alcohol-dependent subjects who were 2 weeks or more postalcohol withdrawal. Their responses were compared with eight nonalcoholic controls. After an overnight fast, each subject received 1.25 mg of bromocriptine orally, and serial samples of GH were taken over a 3-hr period. There was a significantly blunted delta GH response (mean +/- SE) in the alcoholic group, 2.3 mU/liter (+/- 1.4) relative to controls, 7.7 mU/liter (+/- 1.2) (t = 2.96, df = 14, p = 0.01). There was a significantly blunted peak GH response (mean +/- SE) in the alcoholic group, 5.36 mU/liter (+/- 2.1) relative to controls, 9.04 mU/liter (+/- 5.0). This difference also reached statistical significance (t = 2.32, df = 14, p = 0.035). A repeated-measures ANOVA yielded a significant within-subjects effect of time [F(4,54) = 4.08, p = 0.0057], a significant within-subjects effect of group [F(1,14) = 5.6, p = 0.0329], and an almost significant group x time interaction [F(4,54) = 2.45, p = 0.056]. This result implies a relative dopamine D2 receptor subsensitivity in alcoholics in the postwithdrawal period.
在戒酒者的戒断后期评估多巴胺D2受体敏感性。对8名符合《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）酒精依赖标准、已戒酒2周或更长时间的受试者，测量其生长激素（GH）对多巴胺D2激动剂溴隐亭的反应。将他们的反应与8名非酒精依赖对照者进行比较。经过一夜禁食后，每位受试者口服1.25mg溴隐亭，并在3小时内连续采集GH样本。酒精依赖组的GH反应增量（均值±标准误）明显减弱，相对于对照组为2.3mU/升（±1.4），对照组为7.7mU/升（±1.2）（t = 2.96，自由度= 14，p = 0.01）。酒精依赖组的GH反应峰值（均值±标准误）也明显减弱，相对于对照组为5.36mU/升（±2.1），对照组为9.04mU/升（±5.0）。这种差异也具有统计学意义（t = 2.32，自由度= 14，p = 0.035）。重复测量方差分析产生了一个显著的时间内受试者效应[F(4,54) = 4.08，p = 0.0057]，一个显著的组内受试者效应[F(1,14) = 5.6，p = 0.0329]，以及一个几乎显著的组×时间交互作用[F(4,54) = 2.45，p = 0.056]。这一结果表明，戒酒者在戒断后期存在相对的多巴胺D2受体敏感性降低。
