大脑13C-葡萄糖摄取与代谢的核磁共振研究：现状

NMR studies of brain 13C-glucose uptake and metabolism: present status.

作者信息

van Zijl P C, Rothman D

机构信息

Department of Radiology & Biophysics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

出版信息

Magn Reson Imaging. 1995;13(8):1213-21. doi: 10.1016/0730-725x(95)02034-q.

DOI:10.1016/0730-725x(95)02034-q

PMID:8750338

Abstract

One of the common features of epilepsy is a change in glucose metabolism at the site of seizure activity during and between seizures. The noninvasive in situ study of glucose transport and metabolism by NMR can potentially provide detailed information about this phenomena. In this short review, we will discuss the principles of 13C-glucose NMR studies of the brain and compare the advantages and disadvantages of this method to those of 18F-deoxyglucose studies using positron emission tomography (PET).

摘要

癫痫的常见特征之一是在癫痫发作期间及发作间期，癫痫活动部位的葡萄糖代谢会发生变化。通过核磁共振对葡萄糖转运和代谢进行非侵入性原位研究，有可能提供有关这一现象的详细信息。在这篇简短的综述中，我们将讨论大脑13C-葡萄糖核磁共振研究的原理，并比较该方法与使用正电子发射断层扫描（PET）的18F-脱氧葡萄糖研究方法的优缺点。