Schmidt C A, Przybylski G, Seeger K, Siegert W
Abt. Hämatologie und Onkologie, Freie Universität Berlin, Germany.
Leuk Lymphoma. 1995 Dec;20(1-2):45-9. doi: 10.3109/10428199509054752.
In this review we present our data concerning T-cell receptor (TCR) delta gene rearrangements in acute myeloid leukemia with coexpression of T-lymphoid features (CD2/CD4/CD7; Ly+ AML). We found a correlation between TCR delta gene rearrangements and coexpression of these T-lymphoid features. Ten of 66 Ly+ AML and only one of 44 AML cases without this coexpression exhibited TCR delta gene rearrangements (p = .028). In contrast, no correlation was observed between terminal deoxynucleotidyl transferase (TdT) expression and the occurrence of TCR delta gene rearrangements in AML. Rearrangements were found in two of 25 AML with and seven of 71 AML cases without TdT expression. Interestingly, nucleotide sequencing of junctional sites revealed up to 36 N-nucleotides in cases without or with only weak TdT expression indicating downregulation of TdT expression after the TCR rearrangement took place. Complete V delta 1J delta 1 and incomplete D delta 2J delta 1 gene rearrangements were observed most frequently in Ly+ AML. These recombination patterns were similar to patterns observed in acute T-lymphoblastic leukemia with coexpression of myeloid features (My+ T-ALL) suggesting transformation of a common myeloid/T-lymphoid progenitor cell in these cases.
在本综述中，我们展示了关于伴有T淋巴细胞特征共表达（CD2/CD4/CD7；Ly+AML）的急性髓系白血病中T细胞受体（TCR）δ基因重排的数据。我们发现TCRδ基因重排与这些T淋巴细胞特征的共表达之间存在相关性。66例Ly+AML中有10例以及44例无此共表达的AML病例中仅有1例出现TCRδ基因重排（p = 0.028）。相比之下，在AML中未观察到末端脱氧核苷酸转移酶（TdT）表达与TCRδ基因重排的发生之间存在相关性。在25例有TdT表达的AML中有2例以及71例无TdT表达的AML病例中有7例发现了重排。有趣的是，连接位点的核苷酸测序显示，在无TdT表达或仅有微弱TdT表达的病例中，有多达36个N核苷酸，这表明在TCR重排发生后TdT表达下调。在Ly+AML中最常观察到完整的Vδ1Jδ1和不完整的Dδ2Jδ1基因重排。这些重组模式类似于在伴有髓系特征共表达（My+T-ALL）的急性T淋巴细胞白血病中观察到的模式，提示在这些病例中存在一个共同的髓系/T淋巴细胞祖细胞的转化。
