Xiao L, Saeed K, Herd R P
Department of Veterinary Preventive Medicine, Ohio State University College of Veterinary Medicine, Columbus, 43210, USA.
Vet Parasitol. 1996 Jan;61(1-2):165-70. doi: 10.1016/0304-4017(95)00802-0.
Efficacies of albendazole and fenbendazole in suppressing Giardia cyst output of infected calves were evaluated in two clinical trials. In the first trial, 18 naturally infected calves were allocated to an untreated control group (n = 9) and an albendazole-treated group (n = 9). Calves in the treated group were given 20 mg/kg-1 oral albendazole once daily for 3 days. Compared to controls, treated calves showed 98.5%, 97.6% and 90.8% reductions in cysts per gram of feces (cpg) 1, 2 and 6 weeks respectively after the start of treatment. In a second trial, 13 infected calves were allocated to an untreated control group (n = 6) and a fenbendazole-treated group (n = 7). Calves in the treated group were given 10 mg kg-1 fenbendazole orally twice daily for 3 days. Compared to the control group, treatments reduced cpg counts by 100%, 98.5% and 59.5% 1, 2, and 3 weeks respectively after the start of treatment. Both albendazole and fenbendazole appeared to be effective in suppressing cyst excretion by Giardia-infected calves.
在两项临床试验中评估了阿苯达唑和芬苯达唑对抑制受感染小牛贾第虫包囊排出的效果。在第一项试验中，将18头自然感染的小牛分配到未治疗的对照组（n = 9）和阿苯达唑治疗组（n = 9）。治疗组的小牛每天口服一次20 mg/kg的阿苯达唑，持续3天。与对照组相比，治疗后的小牛在治疗开始后1、2和6周时，每克粪便中的包囊数（cpg）分别减少了98.5%、97.6%和90.8%。在第二项试验中，将13头受感染的小牛分配到未治疗的对照组（n = 6）和芬苯达唑治疗组（n = 7）。治疗组的小牛每天口服两次10 mg/kg的芬苯达唑，持续3天。与对照组相比，治疗在治疗开始后1、2和3周时分别使cpg计数降低了100%、98.5%和59.5%。阿苯达唑和芬苯达唑似乎都能有效抑制贾第虫感染小牛的包囊排泄。
