Hydroxyl radical scavengers enhance nitric oxide-evoked acetylcholine release from mouse cerebral cortical neurons.

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作者信息

Ohkuma S, Katsura M, Chen D Z, Guo J L, Kuriyama K

机构信息

Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.

出版信息

Brain Res Mol Brain Res. 1995 Dec 28;34(2):347-50. doi: 10.1016/0169-328x(95)00207-9.

DOI:10.1016/0169-328x(95)00207-9

PMID:8750841

Abstract

The effect of hydroxyl radical scavengers on acetylcholine (ACh) release evoked by nitric oxide (NO) generators and N-methyl-D-aspartate (NMDA) was investigated. Dimethylthiourea enhanced dose-dependently NO generators-evoked ACh release. Similarly, uric acid and mannitol significantly facilitated ACh release evoked by NO generators. The NMDA-induced ACh release was also significantly facilitated by hydroxyl radical scavengers. These scavengers themselves showed no effects on ACh release. These results suggest that hydroxyl radicals may modify the mechanism for NO-evoked ACh release.

摘要