Removal of hydroxyl radical facilitates Ca2+-dependent [3H]GABA release by peroxynitrite. - Suppr | 超能文献

Removal of hydroxyl radical facilitates Ca2+-dependent [3H]GABA release by peroxynitrite.

作者信息

Higo A, Katsura M, Hibino Y, Hara A, Tarumi C, Ohkuma S

机构信息

Department of Pharmacology, Kawasaki Medical School, Matsushima, Kurashiki 701-0192, Japan.

出版信息

Brain Res Mol Brain Res. 1998 Nov 12;62(1):96-100. doi: 10.1016/s0169-328x(98)00245-9.

DOI:10.1016/s0169-328x(98)00245-9

Abstract

We investigated mechanisms for enhancement of peroxynitrite (OONO-; 5 microM)-evoked [3H] gamma-aminobutyric acid (GABA) release. Hydroxyl radical scavengers such as N,N'-dimethylthiourea (DMTU), mannitol, and uric acid, significantly increased OONO--evoked [3H]GABA release, whereas urea showed no effects on the release. Removal of Ca2+ from incubation buffer abolished the enhancement of the release by DMTU, although DMTU showed no effects on the basal release with and without Ca2+ in extracellular space. These results indicate that hydroxyl radical scavengers facilitate OONO--evoked [3H]GABA release dependent on Ca2+.

摘要

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