Laatikainen L, Mattila J
Department of Opthalmology, Oulu University Hospital, Finland.
Graefes Arch Clin Exp Ophthalmol. 1996 Jan;234(1):67-8. doi: 10.1007/BF00186522.
We wanted to evaluate whether intracameral injection of tissue plasminogen activator (tPA) is useful in managing traumatic hyphaema.
Two eyes with total hyphaema after a severe penetrating injury were treated with a single intracameral injection of 25 micrograms of tPA 5 and 14 days after the injury, respectively.
Most of the blood coagulum dissolved within 24 h, and in one of the two eyes the intraocular pressure decreased from 45 to 8 mmHg. The other eye was hypotonic. No re-bleeding or complications related to the use of tPA were noticed.
The results in these two cases suggest that tPA is a useful adjunct in managing total hyphaema.
