Howard G R, Vukich J, Fiscella R G, Farber M D, Goldberg M F
Department of Ophthalmology, UIC Eye Center, University of Illinois, Chicago 60612.
Arch Ophthalmol. 1991 Feb;109(2):272-4. doi: 10.1001/archopht.1991.01080020118055.
Tissue plasminogen activator was used to evaluate the clearance of traumatic hyphema in a rabbit model. A neodymium-YAG laser was used to disrupt iris vessels, creating a traumatic hyphema. Tissue plasminogen activator (1800 IU/0.1 mL) was injected into the anterior chamber 24 hours after creation of the hyphema. Two control groups (one receiving balanced salt solution and one receiving no treatment) were used for comparison. A multivariate analysis of covariance indicated that the greatest difference in hyphema clearance between the groups occurred at days 3, 4, and 5. Five days after tissue plasminogen activator treatment, the mean size of the clot remaining in the anterior chamber was 27% of that of the original hyphema. In control eyes, almost 60% of the original clot remained at day 5. Treatment of animals with tissue plasminogen activator doses of 5000 IU and 10,000 IU produced a substantial increase in repeated bleeding episodes in our rabbit model. We concluded that although the use of tissue plasminogen activator in our rabbit model of traumatic hyphema significantly improved clearance of blood from the anterior chamber, the remaining clot was of such size that the clinical benefit was questionable.
在兔模型中使用组织型纤溶酶原激活剂评估外伤性前房积血的清除情况。使用钕钇铝石榴石激光破坏虹膜血管，造成外伤性前房积血。在前房积血形成24小时后，将组织型纤溶酶原激活剂（1800 IU/0.1 mL）注入前房。使用两个对照组（一个接受平衡盐溶液，一个不接受治疗）进行比较。多变量协方差分析表明，各组之间前房积血清除的最大差异出现在第3、4和5天。组织型纤溶酶原激活剂治疗5天后，前房内残留血凝块的平均大小为原始前房积血的27%。在对照眼中，第5天时几乎60%的原始血凝块仍存在。在我们的兔模型中，用5000 IU和10000 IU剂量的组织型纤溶酶原激活剂治疗动物会使再出血事件大幅增加。我们得出结论，虽然在我们的外伤性前房积血兔模型中使用组织型纤溶酶原激活剂显著改善了前房内血液的清除，但残留血凝块的大小使临床益处存疑。
