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从西非野生黑冠白睑猴(Cercocebus atys)中分离出首例猿猴免疫缺陷病毒及其特性研究

Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa.

作者信息

Chen Z, Telfer P, Reed P, Zhang L, Getti A, Ho D D, Marx P A

机构信息

Department of Microbiology, New York University Medical Center, NY, 10016, US

出版信息

J Med Primatol. 1995 May;24(3):108-15. doi: 10.1111/j.1600-0684.1995.tb00155.x.

DOI:10.1111/j.1600-0684.1995.tb00155.x
PMID:8751049
Abstract

The lineage of HIV-2-like viruses was studied in feral sooty mangabeys (SMs) by serological and genetic methods. Four feral sooty mangabeys were positive for simian immunodeficiency virus (SIV) antibodies and a new isolate, SIVsmSL92a, was obtained. Genetic analysis of gag genes showed that SIVsmSL92a was highly diverse and a distinct sequence subtype within the SIV sm/HIV-2 family. The results showed that SIVsm is the most diverse group of SIVs found thus far in a single monkey species.

摘要

通过血清学和遗传学方法,对野生黑猩猩体内的HIV-2样病毒谱系进行了研究。四只野生黑猩猩的猿猴免疫缺陷病毒(SIV)抗体呈阳性,并获得了一种新的分离株SIVsmSL92a。对gag基因的遗传分析表明,SIVsmSL92a具有高度多样性,是SIV sm/HIV-2家族中的一个独特序列亚型。结果表明,SIVsm是迄今为止在单一猴种中发现的最具多样性的SIV群体。

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