Fucci C, Sandrelli L, Pardini A, Torracca L, Ferrari M, Alfieri O
Division of Cardiac Surgery, Civic Hospital, Brescia, Italy.
Eur J Cardiothorac Surg. 1995;9(11):621-6 discuss 626-7. doi: 10.1016/s1010-7940(05)80107-1.
From January 1987 to July 1994, 299 consecutive patients ranging from 4 to 80 years of age underwent mitral repair for pure valve insufficiency due to degenerative disease (59%), rheumatic disease (23%), endocarditis (12%) or ischemic heart disease (6%). During the initial period, a variety of reparative methods were used following the principles originally described by Carpentier. More recently, in our institution other surgical techniques have been introduced: specifically, prolapse of the anterior leaflet was corrected either by replacing the chordae with polytetrafluoroethylene (PTFE) sutures or simply by anchoring the prolapsing free edge to the facing edge of the posterior leaflet ("edge-to-edge" technique). Chordal transposition has also been used occasionally to correct the prolapse of the anterior leaflet. The hospital mortality rate was 1.3%. According to actuarial methods, the overall survival rate was 94% at 7 years, and freedom from reoperation was 86%. Significant incremental risk factors for reoperation were: no use of prosthetic ring, correction of the prolapse of the anterior leaflet by triangular resection or chordal shortening and ischemic etiology of the mitral insufficiency (freedom from reoperation at 7 years was 61%, 56% and 51%, respectively). In the late postoperative period (mean follow-up 3.6 years), 95% of the patients were in NYHA class I or II; four patients had thromboembolic episodes, two hemorrhagic complications and two endocarditis. No patient in whom the prolapse of the anterior leaflet was corrected by the recently introduced technique has required reoperation. The anterior mitral leaflet prolapse was therefore neutralized as an incremental risk factor for reoperation and this has contributed to the improved overall results of mitral valve repair.
1987年1月至1994年7月,299例年龄在4岁至80岁之间的连续患者因退行性疾病(59%)、风湿性疾病(23%)、心内膜炎(12%)或缺血性心脏病(6%)导致单纯瓣膜关闭不全而接受二尖瓣修复术。在最初阶段,遵循Carpentier最初描述的原则使用了多种修复方法。最近,在我们机构引入了其他手术技术:具体而言,前叶脱垂通过用聚四氟乙烯(PTFE)缝线替换腱索或简单地将脱垂的游离边缘固定到后叶的相对边缘(“边缘对边缘”技术)来纠正。腱索转位也偶尔用于纠正前叶脱垂。医院死亡率为1.3%。根据精算方法,7年时总体生存率为94%,无需再次手术的比例为86%。再次手术的显著增加风险因素为:未使用人工瓣膜环、通过三角形切除或腱索缩短纠正前叶脱垂以及二尖瓣关闭不全的缺血性病因(7年时无需再次手术的比例分别为61%、56%和51%)。在术后晚期(平均随访3.6年),95%的患者处于纽约心脏协会(NYHA)I级或II级;4例患者发生血栓栓塞事件,2例出现出血并发症,2例发生心内膜炎。采用最近引入的技术纠正前叶脱垂的患者均无需再次手术。因此,二尖瓣前叶脱垂作为再次手术的增加风险因素被消除,这有助于改善二尖瓣修复的总体结果。