网状内皮组织增殖病病毒：与哺乳动物C型逆转录病毒免疫关系的检测
Reticuloendotheliosis virus: detection of immunological relationship to mammalian type C retroviruses.
作者信息
Charman H P, Gilden R V, Oroszlan S
出版信息
J Virol. 1979 Mar;29(3):1221-5. doi: 10.1128/JVI.29.3.1221-1225.1979.
Abstract
Reticuloendotheliosis virus (REV) p30 shares cross-reactive determinants and a common NH2-terminal tripeptide with mammalian type C viral p30's. An interspecies competition radioimmunoassay was developed, using iodinated REV p30 and a broadly reactive antiserum to mammalian virus p30's. The avian leukosis-sarcoma viruses and mammalian non-type C retroviruses did not compete in this assay. Previous data indicating that the REV group is not represented completely in normal avian cell DNA lead us to speculate that this may be the first example of interclass transmission, albeit in the remote past, among the Retroviridae.
摘要
网状内皮组织增殖病病毒（REV）p30与哺乳动物C型病毒p30具有交叉反应性决定簇和共同的氨基末端三肽。利用碘化的REV p30和针对哺乳动物病毒p30的广泛反应性抗血清，开发了一种种间竞争放射免疫测定法。禽白血病-肉瘤病毒和哺乳动物非C型逆转录病毒在该测定法中不产生竞争。先前的数据表明，正常禽细胞DNA中并未完全呈现REV组，这使我们推测，这可能是逆转录病毒科中跨类别传播的首个例子，尽管发生在遥远的过去。
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