腐生葡萄球菌的血凝素是尿路上皮细胞的主要黏附素。
The hemagglutinin of Staphylococcus saprophyticus is a major adhesin for uroepithelial cells.
作者信息
Meyer H G, Wengler-Becker U, Gatermann S G
机构信息
Department of Medical Microbiology and Hygiene, University of Mainz, Germany.
出版信息
Infect Immun. 1996 Sep;64(9):3893-6. doi: 10.1128/iai.64.9.3893-3896.1996.
Abstract
The 160-kDa hemagglutinin of Staphylococcus saprophyticus also serves as a fibronectin-binding protein, and the two activities may be present on different parts of the molecule. Bacteria expressing the 160-kDa hemagglutinin bound in large numbers to histological sections of human ureters, whereas nonhemagglutinating bacteria did not bind. Binding was decreased by an antiserum to the 160-kDa protein and by a preparation of sheep erythrocyte membranes. Fibronectin had no effect. We therefore conclude that binding of S. saprophyticus to uroepithelial cells is mediated by the hemagglutinating activity of the 160-kDa surface protein.
摘要
腐生葡萄球菌的160-kDa血凝素也作为一种纤连蛋白结合蛋白，这两种活性可能存在于分子的不同部位。表达160-kDa血凝素的细菌大量结合于人输尿管的组织切片，而非血凝性细菌则不结合。用针对160-kDa蛋白的抗血清和绵羊红细胞膜制剂可降低结合。纤连蛋白无作用。因此，我们得出结论，腐生葡萄球菌与尿路上皮细胞的结合是由160-kDa表面蛋白的血凝活性介导的。
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