铁的可利用性会影响单核细胞增生李斯特菌进入肠上皮样细胞系Caco-2。
Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2.
作者信息
Conte M P, Longhi C, Polidoro M, Petrone G, Buonfiglio V, Di Santo S, Papi E, Seganti L, Visca P, Valenti P
机构信息
Institute of Microbiology, University of Rome La Sapienza, Italy.
出版信息
Infect Immun. 1996 Sep;64(9):3925-9. doi: 10.1128/iai.64.9.3925-3929.1996.
Abstract
The influence of iron on the entry of Listeria monocytogenes into Caco-2 cells was studied. Iron availability was found to modify the surface hydrophobicity and protein profile of L. monocytogenes, with the result that cell invasion strongly increased upon bacterial growth in iron-rich medium. The enhanced invasive capability of iron-overloaded L. monocytogenes cells correlates to the higher-level expression of the inlAB virulence genes, which were positively iron regulated at the transcriptional level.
摘要
研究了铁对单核细胞增生李斯特菌进入Caco-2细胞的影响。发现铁的可利用性会改变单核细胞增生李斯特菌的表面疏水性和蛋白质谱，结果是在富含铁的培养基中细菌生长时细胞侵袭力显著增加。铁过载的单核细胞增生李斯特菌细胞增强的侵袭能力与inlAB毒力基因的更高水平表达相关，这些基因在转录水平上受到铁的正向调控。
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