Franco M A, Feng N, Greenberg H B
Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
J Infect Dis. 1996 Sep;174 Suppl 1:S47-50. doi: 10.1093/infdis/174.supplement_1.s47.
Rotavirus-induced diarrhea is responsible for the death of approximately 800,000 children per year. Jennerian and modified Jennerian anti-rotavirus vaccines currently being tested have a moderate protective effect against rotavirus disease. Optimization of these vaccines, development of more efficient rationally designed vaccines, and identification of other strategies to prevent or treat rotavirus disease will rely on a thorough understanding of the host-virus relationship and especially on the immune mechanisms developed by the host against rotavirus. Recent advances in our understanding of the mouse model of rotavirus infection will enhance the understanding of human rotavirus disease.
轮状病毒引起的腹泻每年导致约80万儿童死亡。目前正在测试的詹纳氏和改良詹纳氏抗轮状病毒疫苗对轮状病毒疾病有一定的保护作用。优化这些疫苗、开发更有效的合理设计疫苗以及确定预防或治疗轮状病毒疾病的其他策略将依赖于对宿主-病毒关系的透彻理解，尤其是对宿主针对轮状病毒形成的免疫机制的理解。我们对轮状病毒感染小鼠模型认识的最新进展将增进对人类轮状病毒疾病的了解。
