FtsZ与细胞分裂抑制剂之间的相互作用。
Interaction between FtsZ and inhibitors of cell division.
作者信息
Huang J, Cao C, Lutkenhaus J
机构信息
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66103, USA.
出版信息
J Bacteriol. 1996 Sep;178(17):5080-5. doi: 10.1128/jb.178.17.5080-5085.1996.
Abstract
The interaction between inhibitors of cell division and FtsZ were assessed by using the yeast two-hybrid system. An interaction was observed between FtsZ and SulA, a component of the SOS response, and the interacting regions were mapped to their conserved domains. This interaction was reduced by mutations in sulA and by most mutations in ftsZ that make cell refractory to sulA. No interaction was detected between FtsZ and MinCD, an inhibitory component of the site selection system. However, interactions were observed among various members of the Min system, and MinE was found to reduce the interaction between MinC and MinD. The implications of these findings for cell division are discussed.
摘要
通过酵母双杂交系统评估细胞分裂抑制剂与FtsZ之间的相互作用。观察到FtsZ与SOS反应的一个组分SulA之间存在相互作用，并且相互作用区域被定位到它们的保守结构域。sulA中的突变以及ftsZ中大多数使细胞对SulA不敏感的突变会减弱这种相互作用。未检测到FtsZ与位点选择系统的抑制性组分MinCD之间存在相互作用。然而，在Min系统的各个成员之间观察到了相互作用，并且发现MinE会减弱MinC与MinD之间的相互作用。讨论了这些发现对细胞分裂的意义。
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Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring.细胞分裂抑制剂SulA和MinCD可阻止FtsZ环的形成。
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Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein.大肠杆菌细胞分裂蛋白FtsZ是一种鸟嘌呤核苷酸结合蛋白。
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