Ohama E, Hinokuma K, Oyanagi K
Division of Neuropathology, Faculty of Medicine, Tottori University.
Rinsho Shinkeigaku. 1995 Dec;35(12):1400-2.
Eighteen autopsy cases of syringomyelia were studied neuropathologically. In 5 cases associated with Chiari type I malformation, the syrinx was irregular in shape and communicated with the subarachnoid space at the entry zone of the posterior nerve roots. The central canal above the level of the syrinx was patent in 2 but closed in 3 out of 5 cases. In cases associated with Chiari type I malformation, communication between the syrinx and the subarachnoid space was considered to play an important role in the pathogenesis of syringomyelia. In 6 cases associated with Chiari type II malformation, the syrinx central canal, and the central canal was patent from the 4th ventricle to the syrinx in all cases. In these cases, direct continuity between the 4th ventricle and the syrinx was essential for the development of the syrinx. In cases associated with posterior fossa or spinal canal tumors, the local circulatory disturbance and/or edema due to the tumors were thought to cause the syrinx.
对18例脊髓空洞症尸检病例进行了神经病理学研究。在5例合并Chiari I型畸形的病例中，空洞形状不规则，在后神经根进入区与蛛网膜下腔相通。空洞水平以上的中央管在5例中有2例通畅，但有3例闭合。在合并Chiari I型畸形的病例中，空洞与蛛网膜下腔之间的交通被认为在脊髓空洞症的发病机制中起重要作用。在6例合并Chiari II型畸形的病例中，空洞、中央管均存在，且在所有病例中中央管从第四脑室至空洞均通畅。在这些病例中，第四脑室与空洞之间的直接连续性对于空洞的形成至关重要。在合并后颅窝或椎管肿瘤的病例中，肿瘤引起的局部循环障碍和/或水肿被认为是导致空洞形成的原因。
