Imai T, Arai T
Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University.
Nihon Sanka Fujinka Gakkai Zasshi. 1996 Jun;48(6):405-11.
The amount of Leukotriene B4 (LTB4) released from neutrophilic leukocyte activated by calcium ionophore was measured to examine neutrophilic functions regarding the changes during normal pregnancy and differences between normal pregnant women and preeclamptic women. In addition, we examined the arachidonic acid (AA) content and fatty acid composition of neutrophilic phospholipid in normal pregnant women. In a normal pregnancy, the amount of LTB4 released decreased significantly with gestation. In preeclamptic women, the amount of LTB4 released was significantly higher than that in normal pregnant women, but there was no significant difference from non-pregnant women. Normal pregnant women showed a significantly decreased AA content with gestation. Regarding other fatty acids, as to fatty acid composition, there was increased saturated fatty acid and decreased unsaturated fatty acid with gestation. The results suggested that the LTB4 released was inhibited more in pregnant women than in non-pregnant women, and pregnant women also had decreased AA content. In addition, changes in fatty acid compositions showed signs of decreased fluidity of the cell membrane. This phenomenon is thought to be due to a mechanism to inhibiting the activation of neutrophilic leukocytes accompanied by a decrease in the amount of LTB4 released. Conversely, no similar inhibition was observed in preeclamptic women, and the failure of this mechanism seemed to contribute to the development of preeclampsia.
通过测量钙离子载体激活的中性粒细胞释放的白三烯B4（LTB4）量，来研究正常妊娠期间中性粒细胞功能的变化以及正常孕妇与子痫前期孕妇之间的差异。此外，我们还检测了正常孕妇中性粒细胞磷脂的花生四烯酸（AA）含量和脂肪酸组成。在正常妊娠中，LTB4释放量随孕周显著降低。子痫前期孕妇LTB4释放量显著高于正常孕妇，但与未孕女性无显著差异。正常孕妇的AA含量随孕周显著降低。关于其他脂肪酸，从脂肪酸组成来看，饱和脂肪酸随孕周增加，不饱和脂肪酸随孕周减少。结果表明，孕妇释放的LTB4比未孕女性受到更多抑制，且孕妇的AA含量也降低。此外，脂肪酸组成的变化显示出细胞膜流动性降低的迹象。这种现象被认为是由于一种机制，即伴随着LTB4释放量的减少抑制中性粒细胞的激活。相反，子痫前期孕妇未观察到类似的抑制作用，这种机制的失效似乎促成了子痫前期的发展。
