Takemura M, Seishima M, Noma A, Kasai C, Satoh M, Morita T, Takeuchi S
Central Clinical Laboratory, Gifu University Hospital.
Rinsho Byori. 1996 Jun;44(6):564-8.
It has been recently shown that soluble interleukin-2 receptor (sIL-2R) is related to the pathogenesis of autoimmune diseases. We determined serum levels of sIL-2R in patients with rheumatoid arthritis (RA). Fifty-three patients (3 males and 50 females from 35 to 70 years old) and sex- and age-matched 50 healthy subjects were included in this study. The sIL-2R concentrations positively correlated with Lansbury index of RA (r = 0.602, p < 0.01). There was a significant correlation between sIL-2R levels and the prevalence of CD3+.HLA-DR+ lymphocytes (r = 0.420, p < 0.01).
最近研究表明，可溶性白细胞介素-2受体（sIL-2R）与自身免疫性疾病的发病机制相关。我们测定了类风湿关节炎（RA）患者血清中sIL-2R的水平。本研究纳入了53例患者（3例男性和50例女性，年龄在35至70岁之间）以及50名年龄和性别匹配的健康受试者。sIL-2R浓度与RA的兰斯伯里指数呈正相关（r = 0.602，p < 0.01）。sIL-2R水平与CD3⁺.HLA-DR⁺淋巴细胞的患病率之间存在显著相关性（r = 0.420，p < 0.01）。
