Nagasaka H, Taguchi M, Mizumoto Y, Hori K, Hayashi K, Sugai M, Murakami Y, Oohara K, Matsumoto I, Hori T
Department of Anesthesiology, Saitama Medical School.
Masui. 1996 Jun;45(6):750-5.
The influence of timing of administration of preoperative pentazocine on pain and analgesic requirements after surgery was studied in 46 patients undergoing total abdominal hysterectomy. Twenty-three patients received thiamylal 5 mg.kg-1 on induction of anesthesia, followed by pentazocine 30 mg or 60 mg before surgical incision (group A). Twenty-three control patients received pentazocine 30 mg or 60 mg, 5 min after abdominal incision (group B). The visual analogue scales for pain 24 h after operation were 6.0 cm at 30 mg dose in group A or 5.3 cm at 60 mg dose in group A and 5.7 cm at 30 mg dose in group B or 4.7 cm at 60 mg dose in group B. There were no differences in the visual analogues scales. Pentazocine consumption in the first 24 h after surgery was 67.5 mg at 30 mg dose in group A or 52.5 mg at 60 mg dose in group A and 70.9 mg at 30 mg dose in group B or 51.8 mg at 60 mg dose in group B. We conclude that postoperative pentazocine consumption and pain scores are no different when pentazocine is given before or after skin incision for abdominal hysterectomy and that there is no clinically useful pre-emptive analgesic effect with these doses of pentazocine.
对46例行全腹子宫切除术的患者研究了术前喷他佐辛给药时间对术后疼痛及镇痛需求的影响。23例患者在麻醉诱导时给予硫喷妥钠5mg·kg-1，然后在手术切口前给予喷他佐辛30mg或60mg（A组）。23例对照患者在腹部切口后5分钟给予喷他佐辛30mg或60mg（B组）。术后24小时疼痛视觉模拟量表评分在A组30mg剂量时为6.0cm，60mg剂量时为5.3cm；在B组30mg剂量时为5.7cm，60mg剂量时为4.7cm。视觉模拟量表评分无差异。术后24小时内喷他佐辛的消耗量在A组30mg剂量时为67.5mg，60mg剂量时为52.5mg；在B组30mg剂量时为70.9mg，60mg剂量时为51.8mg。我们得出结论，对于腹式子宫切除术，在皮肤切口前或后给予喷他佐辛，术后喷他佐辛的消耗量和疼痛评分无差异，且这些剂量的喷他佐辛无临床有效的超前镇痛作用。
