Davies J D, Martin G, Phillips J, Marshall S E, Cobbold S P, Waldmann H
Department of Pathology, Cambridge University, United Kingdom.
J Immunol. 1996 Jul 15;157(2):529-33.
An encounter of the mature immune system with Ag usually leads to an immune response. If Ag is administered with CD4- and CD8-specific mAbs, the outcome of the response can be tolerance. This form of tolerance is peripheral, Ag specific, and maintained lifelong, and is associated with the suppression of nontolerant cells by CD4 cells of the tolerant host. Here we demonstrate that the degree of suppression is dependent on the number of suppressor cells. A neutralizing anti-IL-4 Ab was partially able to inhibit suppression, indicating a role for IL-4 in the regulation of Th1 rejection responses.
成熟免疫系统与抗原的相遇通常会引发免疫反应。如果抗原与CD4和CD8特异性单克隆抗体一起给药，反应结果可能是耐受。这种耐受形式是外周性的、抗原特异性的且终身维持，并且与耐受宿主的CD4细胞对非耐受细胞的抑制有关。在这里，我们证明抑制程度取决于抑制细胞的数量。一种中和性抗IL-4抗体能够部分抑制抑制作用，表明IL-4在Th1排斥反应的调节中起作用。
