Ichikawa H, Takahashi T, Ogiwara H, Sakata K, Otaki A, Suzuki M, Oya T, Tomizawa N, Ishikawa S, Morishita Y
Second Department of Surgery, Gunma University School of Medicine, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1996 Jun;44(6):755-9.
For preventing graft failure, the effects of hypothermic management of brain dead dogs was investigated. Forty-three brain dead dogs were divided into two groups according to the degree of esophageal temperature; a normothermic group (37.2 +/- 0.3 degree C, mean +/- SEM, n = 22), and a hypothermic group (31.8 +/- 0.3 degree C, n = 21) which was obtained by introducing ice slush in the peritoneal cavity. During the management of brain dead dogs, 1) heart rate, pressure product, and a total amount of catecholamine were significantly lower (p < 0.05) in the hypothermic group than in the normothermic group, 2) mean blood pressure, the maximum rate of the rise of left ventricle (LVdp/dt) and cardiac output were not different between both groups, 3) lactate content in the coronary sinus, and O2-extraction rate of the heart tended to be lower in the hypothermic group than in the normothermic group. After transplantation, the recovery of cardiac function was better in the hypothermic group than in the normothermic group. Hypothermic management of brain dead dogs may safely decrease cardiac stress, and keep cardiac aerobic circumstances.
为预防移植物功能衰竭，研究了脑死亡犬低温管理的效果。43只脑死亡犬根据食管温度分为两组：正常体温组（37.2±0.3℃，平均值±标准误，n = 22）和低温组（31.8±0.3℃，n = 21），低温组通过向腹腔内注入碎冰获得。在脑死亡犬的管理过程中，1）低温组的心率、压力乘积和儿茶酚胺总量显著低于正常体温组（p < 0.05），2）两组间平均血压、左心室最大上升速率（LVdp/dt）和心输出量无差异，3）低温组冠状窦中的乳酸含量和心脏的氧摄取率往往低于正常体温组。移植后，低温组的心脏功能恢复优于正常体温组。脑死亡犬的低温管理可能安全地降低心脏应激，并保持心脏有氧环境。
