Wang C J, Howng S L
Department of Surgery, Kaohsiung Medical College, Taiwan, Republic of China.
Kaohsiung J Med Sci. 1996 Jul;12(7):394-9.
Cell cultures of 7 micro- and 16 macroprolactinomas obtained from twenty-three patients (10 males and 13 females) by transsphenoidal adenomectomies were found to be capable of secreting hormones in vitro. Prolactin levels in the culture media were measured during the culture periods and showed that the high PRL levels in culture media may indicate early relapse. Morphological features of both micro- and macroprolactinomas in vitro resembled those of the original tumors. Most macroprolactinomas harbored densely-granulated cells, while most microprolactinomas sparsely-granulated cells. The cell culture techniques combined with morphological studies of prolactinomas allow further investigation of structure-function correlation in human prolactinomas.
通过经蝶窦腺瘤切除术从23例患者（10例男性和13例女性）获得的7例微泌乳素瘤和16例大泌乳素瘤的细胞培养物被发现能够在体外分泌激素。在培养期间测量了培养基中的催乳素水平，结果表明培养基中高催乳素水平可能预示早期复发。微泌乳素瘤和大泌乳素瘤在体外的形态学特征与原发肿瘤相似。大多数大泌乳素瘤含有密集颗粒细胞，而大多数微泌乳素瘤含有稀疏颗粒细胞。细胞培养技术与泌乳素瘤的形态学研究相结合，有助于进一步研究人类泌乳素瘤的结构-功能相关性。
