Stefăneanu L, Taşcă C, Coculescu M
Endocrinologie. 1981 Oct-Dec;19(4):243-8.
Authors studied ten cases of human pituitary adenomas, using light and electron microscopical techniques. Based on morphological features correlated with endocrine symptomatology, seven adenomas proved to be functional and three were nonfunctional. The seven secretory adenomas were classified as follows : somatotropic adenomas with densely granulated cells (1 case); prolactinomas with sparsely granulated cells (3 cases); and mixed somatotroph cell - prolactin cell adenomas (3 cases). The nonfunctional tumors belonged to the undifferentiated cell adenoma type. The cells of the densely granulated adenoma resembled the normal cell from which they derived. In the sparsely granulated tumors the secretory granules were smaller and more nonspecific than those of the normal pituitary cells. The cells of the undifferentiated adenomas had sparse organelles and often showed oncocytic transformation. The ultrastructural characteristics of the adenomas are discussed in relation with the type of hormonal secretion and proliferative propension.
作者运用光学和电子显微镜技术研究了10例人类垂体腺瘤。根据与内分泌症状相关的形态学特征，7例腺瘤被证明具有功能性，3例为无功能性。7例分泌性腺瘤分类如下：密集颗粒细胞生长激素腺瘤（1例）；稀疏颗粒细胞催乳素腺瘤（3例）；混合生长激素细胞 - 催乳素细胞腺瘤（3例）。无功能性肿瘤属于未分化细胞腺瘤类型。密集颗粒腺瘤的细胞类似于其来源的正常细胞。在稀疏颗粒肿瘤中，分泌颗粒比正常垂体细胞的更小且更不具特异性。未分化腺瘤的细胞细胞器稀少，常表现为嗜酸性变。结合激素分泌类型和增殖倾向对腺瘤的超微结构特征进行了讨论。
