Atzpodien W, Hüwels G, Kremer G J, Schnellbacher E
Klin Wochenschr. 1977 May 1;55(9):457-9. doi: 10.1007/BF01488584.
There are mainly four neutral glycosphingolipids in human blood plasma: Monohexosyl, dihexosyl, trihexosyl and tetrahexosyl ceramide. In patients with viral hepatitis (n=21) during the acute phase all four fractions of plasma glycosphingolipids were elevated compared to healthy subjects (n=23). With the exception of trihexosyl ceramide all fractions demonstrated statistically striking elevations in the acute phase of viral hepatitis. Simultaneously in the acute phase of hepatitis triglycerides and cholesterol in serum were significantly increased. It is concluded the elevation of glycosphingolipid levels in plasma is a metabolic consequence of hyperlipoproteinemia. Furthermore it is supposed that a part of plasma glycosphingolipids is synthezised de novo by the liver like VLDL.
单己糖神经酰胺、二己糖神经酰胺、三己糖神经酰胺和四己糖神经酰胺。在急性期的病毒性肝炎患者（n = 21）中，与健康受试者（n = 23）相比，血浆糖鞘脂的所有四个组分均升高。除三己糖神经酰胺外，所有组分在病毒性肝炎急性期均表现出统计学上显著的升高。同时，在肝炎急性期，血清中的甘油三酯和胆固醇显著增加。得出的结论是，血浆中糖鞘脂水平的升高是高脂蛋白血症的代谢后果。此外，推测血浆中的一部分糖鞘脂像极低密度脂蛋白一样由肝脏从头合成。
