Vergani C, Trovato G, Delù A, Pietrogrande M, Dioguardi N
J Clin Pathol. 1978 Aug;31(8):772-8. doi: 10.1136/jcp.31.8.772.
Serum total lipids, lipoprotein cholesterol, apolipoprotein A (Apo A), and liver function tests have been investigated in patients with acute viral hepatitis and chronic liver disease. Hypertriglyceridaemia, absence of alpha and pre beta bands on the lipoprotein electrophoresis pattern, low level of Apo A, and presence of abnormal lipoproteins (beta-VLDL and beta2-LP) were observed in the early phase of acute hepatitis. A positive correlation was found between Apo A and high-density lipoprotein cholesterol, and a negative one between Apo A and triglyceride, bile acids, total bilirubin, and serum alanine aminotransferase. Lipoprotein abnormalities found in the early phase of acute hepatitis are probably due to low lecithin-cholesterol acyltransferase activity. The reappearance of alpha lipoprotein and the increase of Apo A are sensitive indices of improvement of liver function. In chronic liver disease low levels of cholesterol and Apo A indicate the severity of liver cell injury.
对急性病毒性肝炎和慢性肝病患者的血清总脂质、脂蛋白胆固醇、载脂蛋白A（Apo A）及肝功能进行了研究。急性肝炎早期可见高甘油三酯血症、脂蛋白电泳图谱上α和前β带缺失、Apo A水平降低以及异常脂蛋白（β-VLDL和β2-LP）的存在。发现Apo A与高密度脂蛋白胆固醇呈正相关，与甘油三酯、胆汁酸、总胆红素及血清丙氨酸转氨酶呈负相关。急性肝炎早期出现的脂蛋白异常可能是由于卵磷脂胆固醇酰基转移酶活性降低所致。α脂蛋白的重现及Apo A的增加是肝功能改善的敏感指标。在慢性肝病中，胆固醇和Apo A水平低提示肝细胞损伤的严重程度。
