Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, People's Republic of China.
Genetic laboratory, Women and Children's Health Care Hospital of Linyi, 276000, Linyi, People's Republic of China.
Mol Cell Biochem. 2019 Jan;450(1-2):97-103. doi: 10.1007/s11010-018-3376-y. Epub 2018 Jun 12.
Aryl hydrocarbon-receptor nuclear translocator (ARNT2) is a member of the bHLH PAS (basic helix-loop-helix Period/ARNT/Single-minded) family of transcription factors. Recently, some studies indicate that ARNT2 is associated with the occurrence and development of carcinoma. However, its roles in gastric cancer (GC) remain unclear. In the present study, we found that ARNT2 expression level is lower in GC tissues compared with adjacent non-tumor tissues, and negatively correlated with depth of invasion of the tumor, differentiated degree, and poor survival of GC patients. Overexpression of ARNT2 inhibits cell proliferation. Furthermore, AKT pathway contributed to ARNT2 -mediated PC proliferation. Taken together, our results provide the first evidence that high expression of ARNT2 inhibited proliferation of GC cells and affected tumor aggressiveness in GC patients.
芳香烃受体核转位蛋白 2（ARNT2）是 bHLH-PAS（基本螺旋-环-螺旋/Period/ARNT/Single-minded）家族转录因子的一员。最近的一些研究表明，ARNT2 与癌的发生和发展有关。然而，其在胃癌（GC）中的作用尚不清楚。在本研究中，我们发现 ARNT2 的表达水平在 GC 组织中低于相邻非肿瘤组织，并且与肿瘤浸润深度、分化程度和 GC 患者的不良生存呈负相关。ARNT2 的过表达抑制细胞增殖。此外，AKT 通路参与了 ARNT2 介导的 PC 增殖。综上所述，我们的研究结果首次提供了证据表明，ARNT2 的高表达抑制了 GC 细胞的增殖，并影响了 GC 患者肿瘤的侵袭性。
