Koliaskina G I, Sekirina T P, Androsova L V, Kushner S G, Vasil'eva E F, Burbaeva O A, Gavrilova S I, Selezneva N D
Vestn Ross Akad Med Nauk. 1996(4):19-23.
The paper presents a review of data available in the literature and the authors' own findings on age-related physiology and pathology of the immune system. Almost all parameters characterizing the functional activity of the immune system in Alzheimer's disease (AD) were demonstrated to significantly differ from those in the healthy elderly, The magnitude of immunological changes clearly correlated with the severity of dementia in AD patients. A hypothesis of the gradual development of immunological changes in an AD patient in relation to his dementia formation is given.
本文对文献中可用的数据以及作者自身关于免疫系统与年龄相关的生理学和病理学研究结果进行了综述。几乎所有表征阿尔茨海默病（AD）患者免疫系统功能活性的参数都被证明与健康老年人的参数有显著差异。免疫变化的程度与AD患者痴呆的严重程度明显相关。文中提出了一个关于AD患者免疫变化与痴呆形成相关的渐进发展假说。
