Fokin V F, Ponomareva N V, Androsova L V, Sekirina T P, Koliaskina G I, Gavrilova S I, Selezneva N D
Vestn Ross Akad Med Nauk. 1996(4):32-9.
Relationships between neurophysiological and immune parameters were studied in normal middle-aged and elderly subjects and in patients with dementia of Alzheimer's type (DAT). The rate of such interaction was minimal in normal aging, in DAT neuroimmune relations increased. The correlation between the immune parameters and the characteristics of components of visual evoked potentials and auditory brain-stem responses suggests that in the middle-aged healthy subjects, a primary role in neuroimmune relations belongs to limbicoreticular structures and to the mesencephalon. In normal aging, the influence of limbicoreticular structures on immune structures decreases. In DAT, the modulation of immune processes by limbicoreticular and thalamocortical structures, as well as the pontobulbar part of the brain stem increases. In middle age and in DAT, persons with different functional brain asymmetry (as estimated from electrophysiological criteria) have different lymphocytic functional activities and rates of neuroimmune interactions.
在正常中年和老年受试者以及阿尔茨海默病型痴呆（DAT）患者中研究了神经生理参数与免疫参数之间的关系。在正常衰老过程中，这种相互作用的速率最小，而在DAT中神经免疫关系增强。免疫参数与视觉诱发电位和听觉脑干反应成分特征之间的相关性表明，在中年健康受试者中，神经免疫关系中的主要作用属于边缘网状结构和中脑。在正常衰老过程中，边缘网状结构对免疫结构的影响减弱。在DAT中，边缘网状结构、丘脑皮质结构以及脑干的脑桥延髓部分对免疫过程的调节增强。在中年和DAT患者中，具有不同功能性脑不对称性（根据电生理标准评估）的人具有不同的淋巴细胞功能活性和神经免疫相互作用速率。
