Chernov G A, Sharygin V L, Pulatova M K, Sharf V G, Borovkov M V, Shliakova T G, Khristianovich D S, Mitrokhin Iu I, Todorov I N
Izv Akad Nauk Ser Biol. 1996 May-Jun(3):282-91.
It was shown that indomethaphen (IM) is capable of stimulation of the synthesis of DNA, RNA, and protein precursors in mice. The IM-induced elevated level of the ribonucleotide reductase activity and, hence, deoxyribonucleotide pool in the spleen at the moment of irradiation and during the early postradiation period provides for complete DNA repair. As a result, the damaging effect of ionizing irradiation is weakened. At later stages (2-20 days) IM activates protein and DNA synthesis leading to the recovery of the ribonucleotide reductase activity in the spleen, on increased content of Fe3(+)-transferrin, cytochrome-c-oxidase, and ferrosulfuric components of the mitochondrial electron transport chain, and increased potential of the detoxication system due to the elevated content of cytochrome P-450. IM stimulates ATP synthesis. Thus, IM enhances compensatory-restorative reactions of the cell systems, more pronounced in the spleen than in the liver.
结果表明，吲哚美辛（IM）能够刺激小鼠体内DNA、RNA和蛋白质前体的合成。在照射时以及照射后的早期，IM诱导脾脏中核糖核苷酸还原酶活性升高，从而使脱氧核糖核苷酸池增加，这有助于DNA的完全修复。因此，电离辐射的损伤作用被减弱。在后期阶段（2 - 20天），IM激活蛋白质和DNA合成，导致脾脏中核糖核苷酸还原酶活性恢复，线粒体电子传递链中Fe3(+)-转铁蛋白、细胞色素c氧化酶和铁硫成分含量增加，由于细胞色素P - 450含量升高，解毒系统的潜能增强。IM刺激ATP合成。因此，IM增强了细胞系统的代偿性恢复反应，在脾脏中比在肝脏中更明显。
