Kustikova O S, Kiselev S L, Borodulina O R, Senin V M, Afanas'eva A V, Kabishev A A
Genetika. 1996 May;32(5):621-8.
Gene expression was compared in a metastatic (VMR-Liv) neoplastic cell line and a related nonmetastatic (VMR-O) neoplastic cell line by means of the differential display method. A fragment of cDNA corresponding to the tag7 gene, differentially expressed in the metastatic cell line, was isolated. The full-length tag7 cDNA was cloned and its nucleotide sequence was determined. No homology between the tag7 gene and known sequences was revealed. tag7 gene transcription was studied in some tumors, cell lines, and normal mouse organs.
通过差异显示法比较了转移性（VMR-Liv）肿瘤细胞系和相关非转移性（VMR-O）肿瘤细胞系中的基因表达。分离出了在转移性细胞系中差异表达的一段对应于tag7基因的cDNA片段。克隆了tag7 cDNA全长并测定了其核苷酸序列。未发现tag7基因与已知序列之间存在同源性。在一些肿瘤、细胞系和正常小鼠器官中研究了tag7基因的转录情况。
