[在易患僵住症的大鼠大脑中5-羟色胺5-HT1A受体的分布]
[The distribution of serotonin 5-HT1A receptors in the brain of rats genetically predisposed to the development of catalepsy].
作者信息
Popova N K, Avgustinovich D F, Shigantsov S N, Kulikov A V
出版信息
Zh Vyssh Nerv Deiat Im I P Pavlova. 1996 May-Jun;46(3):578-82.
[3H]-8-OH-DPAT specific binding was determined in brain regions of S40 rats selected for predisposition to freezing (catalepsy). Significant decrease in Bmax in the frontal cortex and increase in Kd in the hippocampus as well as a strong tendency to a decrease in Bmax in the midbrain and hypothalamus were shown in cataleptic rats. The findings suggest the involvement of serotonin 5-HT1A receptors in the genetic predisposition to fear-induced passive defensive response.
在选择用于诱发僵住（木僵）易感性的S40大鼠的脑区中测定了[3H]-8-羟基二苯丙氨酸（[3H]-8-OH-DPAT）特异性结合。木僵大鼠的额叶皮质中最大结合量（Bmax）显著降低，海马体中解离常数（Kd）升高，中脑和下丘脑的Bmax也有强烈的降低趋势。这些发现表明5-羟色胺5-HT1A受体参与了恐惧诱导的被动防御反应的遗传易感性。
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