Avgustinovich D F
Zh Evol Biokhim Fiziol. 1992 Jul-Aug;28(4):454-8.
The specific radioligand binding of serotonin 5-HT1A and 5-HT2 receptors was determined in the frontal cortex and in the hypothalamus of Norway rats and silver foxes. Aggressive wild rats and silver foxes and animals selected for many generations for nonaggressive behavior towards man (domestication) were compared. The binding of the 5-HT1A receptors was found to be significantly higher in domesticated Norway rats and lower in domesticated foxes than in aggressive animals. The specific binding of the 5-HT2 receptors was found to be similar in aggressive and domesticated animals, both in rats and foxes. The data obtained indicate the involvement of 5-HT1A receptors in the hypothalamus into the process of domestication.
在挪威大鼠和银狐的额叶皮质及下丘脑测定了血清素5-HT1A和5-HT2受体的特异性放射性配体结合。比较了具有攻击性的野生大鼠和银狐以及经过多代选育对人类无攻击行为（驯化）的动物。发现5-HT1A受体的结合在驯化的挪威大鼠中显著更高，而在驯化的狐狸中比在有攻击性的动物中更低。5-HT2受体的特异性结合在有攻击性和驯化的动物中相似，无论是大鼠还是狐狸。所获得的数据表明下丘脑的5-HT1A受体参与了驯化过程。
