Lampreave J L, Bittini A, Mateos F, Manzano S, Domínguez P
Servicio de Medicina Nuclear del Hospital General Universitario Gregorio Maranón, Madrid.
Rev Neurol. 1996 Aug;24(132):921-5.
Tourette's syndrome (GdT) is a chronic neuropsychiatric disorder of unclear etiology characterized clinically by the presence of motor and phonic tics as well as a variety of behavioral and cognitive abnormalities such as Obsessive-Compulsive Disorder (TOC) and Attention Deficit Hyperactivity Disorder (ADHD). Dopaminergic pathway and movement control related structures may have some implications for pathogenesis. Neuroimaging techniques may yield relevant data for a better understanding of the symptoms and physiopathology of this disease. Among them, functional isotopic techniques such as PET and SPECT and other like quantitative EEG are the most remarkable. In this article we intend to perform a thorough review of the most recent literature, contributing with our own experience and discuss the pathogenesis of GdT.
抽动秽语综合征(GdT)是一种病因不明的慢性神经精神障碍,临床特征为运动和发声抽动,以及多种行为和认知异常,如强迫症(TOC)和注意力缺陷多动障碍(ADHD)。多巴胺能通路和与运动控制相关的结构可能对发病机制有一定影响。神经影像学技术可能会产生相关数据,以更好地理解该疾病的症状和生理病理学。其中,正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)等功能性同位素技术以及其他类似的定量脑电图最为突出。在本文中,我们打算对最新文献进行全面综述,并结合我们自己的经验,探讨抽动秽语综合征的发病机制。