足跟部汗孔癌。一例具有不寻常组织学特征的病例报告。
Porocarcinoma of the heel. A case report with unusual histologic features.
作者信息
D'Amato M S, Patterson R H, Guccion J G, White J C, Krasnow S H
机构信息
Department of Veterans Affairs Medical Center, Washington, DC 20422, USA.
出版信息
Cancer. 1996 Aug 15;78(4):751-7. doi: 10.1002/(SICI)1097-0142(19960815)78:4<751::AID-CNCR10>3.0.CO;2-U.
BACKGROUND
Eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct.
METHODS
A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy.
RESULTS
The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squamous tumor cells contained rare intracytoplasmic lumens.
CONCLUSIONS
The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poroma supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct.
背景
小汗腺汗孔癌是一种表皮内汗腺导管的罕见肿瘤。
方法
描述了1例51岁男性右足跟汗孔癌病例，并对相关文献进行综述。对手术切除的肿瘤进行常规组织学和透射电子显微镜检查。
结果
汗孔癌显示出广泛的核多形性，有频繁的多核肿瘤巨细胞，在表皮内有局灶性亲表皮性播散，外周呈小汗腺导管纤维腺瘤样生长模式，起源于相邻的小汗腺汗孔瘤。超微结构上，鳞状肿瘤细胞含有罕见的胞质内管腔。
结论
广泛的核多形性及频繁出现的肿瘤巨细胞是汗孔癌的一个不寻常特征。其在表皮内的亲表皮性播散及其起源于相邻的小汗腺汗孔瘤支持汗孔癌的诊断。肿瘤外周的小汗腺导管纤维腺瘤样生长模式是汗孔癌独特且此前未描述过的特征。鳞状肿瘤细胞中胞质内管腔的存在类似于表皮内汗腺导管的胚胎发育。
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