Zietek Z, Iwan-Zietek I, Kotschy M, Tyloch F
Katedry i Kliniki Urologii, Katedry i Zakładu Patofizjologii AM w Bydgoszczy.
Pol Tyg Lek. 1996 Feb;51(6-9):75-6.
The pre- and postoperative activity was studied of antithrombin III (AT III) and alpha 2-antiplasmin (alpha 2-AP) in blood of 40 patients subjected to transurethral prostatic electroresection due to benign prostatic hyperplasia (BPH). For comparison of the obtained results a control group was formed from patients with other diseases of the genitourinary system with exception of neoplasms. The activity of AT III and alpha 2-AP before the operation was similar to that in the control group. Intraoperatively (day 0) and on the first day after the operation, a statistically significantly lower activity of AT III and alpha 2-AP was found in the patients with BPH in relation to the initial value as well as to the control group. On day 5 after the operation, normalization of AT III and alpha 2-AP activity was found. During operations of the prostate a release occurs of thromboplastins and plasminogen activators initiating the activation of blood clotting and fibrinolysis. The decrease of activity of AT III and alpha 2-AP could be caused by AT III and alpha 2-AP use-up in the process of inhibition of the created thrombin and plasmin.
对40例因良性前列腺增生（BPH）接受经尿道前列腺电切术患者血液中的抗凝血酶III（AT III）和α2-抗纤溶酶（α2-AP）术前及术后活性进行了研究。为比较所得结果，以患有除肿瘤外其他泌尿生殖系统疾病的患者组成对照组。手术前AT III和α2-AP的活性与对照组相似。术中（第0天）及术后第一天，BPH患者中AT III和α2-AP的活性相较于初始值以及对照组在统计学上显著降低。术后第5天，AT III和α2-AP活性恢复正常。前列腺手术过程中会释放凝血活酶和纤溶酶原激活剂，从而启动血液凝固和纤维蛋白溶解的激活过程。AT III和α2-AP活性降低可能是由于在抑制所产生的凝血酶和纤溶酶的过程中AT III和α2-AP被消耗。
