Gupta R, Helms P J, Jolliffe I T, Douglas A S
University Department of Child Health, University of Aberdeen, Scotland, United Kingdom.
Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):431-5. doi: 10.1164/ajrccm.154.2.8756818.
The purpose of this study was to compare epidemiologic features of sudden infant death syndrome (SIDS) and bronchiolitis and to apply statistical examination in order to examine the hypothesis that similar mechanisms could be at work in both conditions. The setting was Scotland from 1982 through 1990. We compared 1,211 deaths from SIDS with 10,058 hospital admissions for bronchiolitis in infancy. The comparisons included age, sex ratio, and seasonality. The sex ratios were similar (SIDS [M:F]:1.61:1; bronchiolitis: 1.63:1), but age distribution was different (chi 2 = 104.6, p < 0.001). When monthly rates throughout the year were compared using correlation of residuals from average season variation and by autocorrelation of residual series, no significant relationships were found between the two conditions (r2 = 0.0004). Once the seasonal pattern common to both conditions was accounted for, SIDS was not autocorrelated between months whereas bronchiolitis exhibited a high level of autocorrelation indicating an epidemic pattern for the latter but not for the former. While a common seasonal variation may indicate some shared etiologic factors associated with winter season, the two conditions do not appear to be closely related. The hypothesis that a common host susceptibility is at work is not supported. Further investigations of seasonal influences are warranted.
本研究的目的是比较婴儿猝死综合征（SIDS）和细支气管炎的流行病学特征，并进行统计检验，以检验两种病症可能存在相似发病机制这一假设。研究范围为1982年至1990年的苏格兰地区。我们将1211例SIDS死亡病例与10058例婴儿期细支气管炎住院病例进行了比较。比较内容包括年龄、性别比和季节性。性别比相似（SIDS[男:女]：1.61:1；细支气管炎：1.63:1），但年龄分布不同（χ² = 104.6，p < 0.001）。当使用平均季节变化的残差相关性和残差序列的自相关性比较全年每月发病率时，未发现两种病症之间存在显著关系（r² = 0.0004）。一旦考虑到两种病症共有的季节性模式，SIDS在各月之间不存在自相关性，而细支气管炎表现出高度自相关性，表明后者呈流行模式，前者则不然。虽然共同的季节性变化可能表明存在一些与冬季相关的共同病因，但这两种病症似乎并无密切关联。共同宿主易感性起作用这一假设未得到支持。有必要进一步研究季节性影响。
