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[替考拉宁在肾移植患者革兰氏阳性菌感染中的应用]

[The use of teicoplanin for Gram-positive infections in patients with kidney transplantation].

作者信息

Jákics J, Gálffy Z, Hernold L, Rácz A, Perner F

机构信息

Semmelweis Orvostudományi Egyetem Transzplantációs Sebészeti Klinika, Budapest.

出版信息

Orv Hetil. 1996 Jun 23;137(25):1355-8.

PMID:8757082
Abstract

Teicoplanin was used for the treatment of multiresistant Gram-positive-Staphylococcus aureus, coagulase negative Staphylococcus and Enterococcus-infections in 15 cases of kidney transplantations. The motive of the application was the once per day dosage and the spare of the transplanted kidney. Nosocomial infections were the most common. Clinical and microbiological diagnosis was the criteria in order to begin the 5-21 days treatment. These patients which were infected with Gram positive bacteria, teicoplanin was also effective in methicillin-resistant cases. In some mixed infections, after several courses of antibiotics, teicoplanin even if combined with other antibiotics could not prevent fatal sepsis.

摘要

替考拉宁用于治疗15例肾移植患者中耐多药革兰氏阳性菌(金黄色葡萄球菌、凝固酶阴性葡萄球菌和肠球菌)感染。应用该药的动机是其每日一次的给药剂量以及对移植肾的保护作用。医院感染最为常见。临床和微生物学诊断是开始为期5至21天治疗的标准。对于这些感染革兰氏阳性菌的患者,替考拉宁对耐甲氧西林的病例也有效。在一些混合感染中,经过几个疗程的抗生素治疗后,即使替考拉宁与其他抗生素联合使用也无法预防致命性败血症。

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