Nemesánszky E, Csepregi A
Gasztroenterológiai és Belgyógyászati Osztály, Országos Reumatológiai és Fizioterápiás Intézet, Budapest.
Orv Hetil. 1996 Jun 16;137(24):1309-13.
The aim of the review is to evaluate the putative clinical interactions between alcohol metabolism and the administration of H2-receptor antagonists. Places of the first-pass metabolism of ethanol in the body have been investigated as well. According to the in vitro experimental results the H2-receptor antagonists can inhibit the ethanol metabolism which may have clinical relevance. When low doses of alcohol (below 0.3 g/kg) are given per os, the administration of H2-receptor antagonists results in an increase in the blood ethanol concentrations. Since that challenged increase never exceeds the level of 0.3/1000 blood alcohol concentration, it has hardly any clinical or medico-legal significance.
本综述的目的是评估酒精代谢与H2受体拮抗剂给药之间可能存在的临床相互作用。同时也对乙醇在体内首过代谢的部位进行了研究。根据体外实验结果，H2受体拮抗剂可抑制乙醇代谢，这可能具有临床相关性。当经口给予低剂量酒精（低于0.3 g/kg）时，给予H2受体拮抗剂会导致血液乙醇浓度升高。由于这种激发性升高从未超过0.3/1000血液酒精浓度水平，因此几乎没有任何临床或法医学意义。
