Shrikant P, Benveniste E N
Department of Cell Biology, University of Alabama at Birmingham 35294, USA.
J Immunol. 1996 Sep 1;157(5):1819-22.
The central nervous system has the capacity to initiate and regulate immune responses by allowing restricted entry of peripheral immune cells and providing a microenvironment that is conducive to the activation of immune effector cells. In this commentary, we discuss the ability of two glial cell types, astrocytes and microglia, to function as APCs. In particular, we focus on the phenotypic and functional distinctions between astrocytes and microglia that may contribute to their differing abilities to effectively present Ag to CD4+ cells.
中枢神经系统能够通过限制外周免疫细胞的进入并提供有利于免疫效应细胞激活的微环境来启动和调节免疫反应。在这篇评论中，我们讨论了两种神经胶质细胞类型，即星形胶质细胞和小胶质细胞作为抗原呈递细胞（APCs）发挥作用的能力。特别是，我们重点关注星形胶质细胞和小胶质细胞之间的表型和功能差异，这些差异可能导致它们在将抗原有效呈递给CD4+细胞方面能力不同。
